Exercise induce oxidative stress in rats kidney

Abstract

Oxygen free radicals play an important role in metabolic and phenotypic adaptation of skeletal muscle to exercise. Recent experimental studies have shown that oxygen free radicals influence the functional activity and thus adaptive metabolic organs, involved in post-exercise recovery and disposal of products of metabolism, plus nerve control structures, gonads and digestive system. Our experimental model aims to quantify the biochemical phenomenon of oxidative stress induced by acute exercise on kidney Wistar rats at 24 hours post-exercise. Male Wistar rats were divided into two groups (control group and the experimental group who performed a single workout, swimming for 90 min), and were sacrificed at 24 hours post-exercise, with the protection of laboratory animals. After slaughter samples were collected from the renal parenchyma and the biochemical parameters followed were: superoxide dismutase activity (SOD) and catalase (CAT) and tissue levels of reduced glutathione (GSH). From the experimental data (superoxide dismutase activity – 6.48±0.19↑ **; catalase activity- 3.80±0.25↑ *; Reduced glutathione levels- 1.63±0.24 NS) that at 24 hours post exercise installs the phenomenon of mild oxidative stress on kidney.

Key words:

exercise, oxidative stress, kidney

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