Functional results of periarticular multimodal injection for reducing pain during total knee prosthesis surgery: a randomized-controlled trial

Abstract

The study aim was to investigate the effect of periarticular drug injection during total knee arthroplasty surgery on postoperative mobility and functional status in early period.
Material and Method. In this prospective study, 40 patients undergoing total knee prosthesis were included. Participants were divided into 2 groups randomly. The intervention group (n = 20) underwent standard surgical procedures with periarticular multimodal cocktail (containing 1 ml Morfin, 1 ml Adrenalin, 1 gr Sefazolin, 20 ml Marcain, 1 ml Depomedrol, 27 ml Physiological Saline solution). The control group (n = 20) underwent standard surgical procedure only. The same rehabilitation program was applied to the participants in both groups received the same rehabilitation program on first day after operation. The program continued as a home exercise regime. Pain intensity and range of motion of knee joint were measured three times after surgery: second day, 15th day and 30th day. Functional level was recorded with Knee Society Knee Arthroplasty Evaluation Form after one month. The two groups were compared using by Shapiro Wilk test and Mann-Whitney U test.
Results: There were significant differences in pain intensity between the two groups at second day and 30 th day (p<0,05). The significant difference was in favor of intervention group. When the two groups were compared in terms of range of motion of the knee, there were no significant differences (p>0,05). There were significant differences between the two groups in terms of Knee Society Knee Arthroplasty Evaluation scores/Knee Score (p<0,05).
Conclusion: The results of the study indicate that using multimodal cocktail can be used to decrease pain, which indicate functions of the knee after total knee prosthesis surgery.

Key words:

total knee prosthesis, multimodal injection, pain, range of motion

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